The All by All tables have recently been released for controlled tier users in the All of Us Researcher Workbench, providing a robust resource for exploring genetic and phenotypic associations. Using short-read whole genome sequencing data, genome-wide association studies (GWAS) and rare variant association studies (RVAS) were conducted, offering researchers the ability to examine a wide range of complex human traits. These All by All tables contain association test results for genes, variants, and phenotypes, making them an ideal tool for researchers with little to no coding experience.
To help researchers get started, the HSLS MolBio Service offers consultations, holds office hours, and provides access to a community workspace All by All template that simplifies data import. This template is specifically designed to load the All by All tables, ensuring that users can focus on their research without being slowed down by technical barriers.
The All by All tables leverage genomic and phenotypic data from nearly 250,000 participants with short-read whole genome sequencing. The dataset spans approximately 3,400 phenotypes, categorized into six groups:
- Physical measurements
- Lab measurements
- Phecodes
- PhecodeX
- Personal and family health history (PFHH)
- Medications sourced from electronic health records (EHR)
By utilizing this extensive resource, researchers can significantly reduce the time and costs associated with data analysis. For more information or to schedule a consultation, reach out to the HSLS MolBio Service and start exploring the All by All data today!
~Alexis Cenname