KEGG (Kyoto Encyclopedia of Genes and Genomes) is a database resource that integrates genomic, chemical and systemic functional information. In particular, gene catalogs from completely sequenced genomes are linked to higher-level systemic functions of the cell, the organism and the ecosystem.
Major efforts have been undertaken to manually create a knowledge base for such systemic functions by capturing and organizing experimental knowledge in computable forms; namely, in the forms of molecular networks called KEGG pathway maps, BRITE functional hierarchies and KEGG modules. Continuous efforts have also been made to develop and improve the cross-species annotation procedure for linking genomes to the molecular networks through the KEGG Orthology (KO) system.
As the result, KEGG is widely used as a reference knowledge base for integration and interpretation of large-scale datasets generated by genome sequencing and other high-throughput experimental technologies. In addition to maintaining the aspects to support basic research, KEGG is being expanded towards more practical applications integrating human diseases, drugs and other health-related substances.
KEGG is developed by Kanehisa Laboratories.
To register, please go here. You must have a Pitt email address, and access is limited to on-campus computers. KEGG will run on PC, Mac, & Linux.