- What: Stratifying breast cancer tissues to understand their molecular characteristics for target identification–MetaCore webinar by Thomson Reuters
- When: 10-11 am on Thursday, 23 July 2015
- Where: Your computer
- How: Register here
- Why: Recently, the role of stromal tissue has been revealed as significant in the cancer progression. Much of the influence from the stroma for tumor growth has been shown via secretion of soluble factors. Finding the way in which stromal and epithelial tissues interact and understanding the importance of supporting tissues in tumor development can lead to new therapeutic targets.
In this webinar, we will use enrichment analysis, interactome and network building tools in MetaCore to analyse transcriptomic data from stroma and epithelia of invasive breast cancer taken from PMID: 18373191 with GEO Series entry GSE10797 as the input datasets, to answer these questions:
- What are the commonalities and differences in expression between the epithelial and stromal tissues in aggressive breast cancer, and how does this translate into pathway perturbation?
- How significantly do the two tissues interact and what if any is the direction of that interactivity?
- What are the key molecules responsible for this interaction and what can we understand about the mechanisms that drive this relationship; how does stromal tissue help promote tumor development?